Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility
نویسندگان
چکیده
منابع مشابه
Linking molecular affinity and cellular specificity in cadherin-mediated adhesion.
Many cell-cell adhesive events are mediated by the dimerization of cadherin proteins presented on apposing cell surfaces. Cadherin-mediated processes play a central role in the sorting of cells into separate tissues in vivo, but in vitro assays aimed at mimicking this behavior have yielded inconclusive results. In some cases, cells that express different cadherins exhibit homotypic cell sorting...
متن کاملCadherin-mediated cellular signaling.
Recent cadherin studies focusing on cellular signaling have shown that several pathways are activated by cadherin-mediated cell-cell contact. Cadherin-mediated contacts activate Rho family GTPases, regulate the availability of beta-catenin to participate in Wnt signaling, and function in receptor tyrosine kinase signaling. Although different classical cadherins bind to the same cytosolic protei...
متن کاملThe Effect of Cellular Phone Microwave Radiation on Sperm Fertility Indices (Count, Motility, Viability and Morphology) in Mice
Background & objectives: Cell phone microwave (MW) is one of the most harmful physical agents in modern society. This study was designed to determine the effects of exposure to cell phone microwaves on mice sperm morphologic indices. Methods: Animals were divided into two groups including: Microwave (MW) (n=6; exposed to 950-MHz cell phone MW with 5 W output power density and 200 KHz modulatio...
متن کاملCellular Adhesion and Adhesion Molecules
In recent years, cell adhesion and cell adhesion molecules have been shown to be important for many normal biological processes, including embryonic cell migration, immune system functions and wound healing. It has also been shown that they contribute to the pathogenesis of a large number of common human disorders, such as rheumatoid arthritis and tumor cell metastasis in cancer. In this review...
متن کاملCadherin-11 Provides Specific Cellular Adhesion between Fibroblast-like Synoviocytes
Cadherins are integral membrane proteins expressed in tissue-restricted patterns that mediate homophilic intercellular adhesion. During development, they orchestrate tissue morphogenesis and, in the adult, they determine tissue integrity and architecture. The synovial lining is a condensation of fibroblast-like synoviocytes (FLS) and macrophages one to three cells thick. These cells are embedde...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncogene
سال: 1999
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1202790